Santa Cruz 2 challenger · ATP
Santa Cruz 2 challenger 2022
ChallengerClaySanta Cruz de la Sierra, Bolivia20 March – 27 March 2022Prize money: 53,120 USD49 matchesAltitude: 419 mCourt: Medium
Champion Paul Jubb · Final: 6-3 7-6(4)
Final rounds
| Final | Paul Jubb vs Juan Pablo Varillas | 6-3 7-6(5) |
| Semifinal | Juan Pablo Varillas vs Pablo Cuevas | 6-2 6-4 |
| Semifinal | Paul Jubb vs Daniel Dutra da Silva | 6-4 7-5 |
| Quarterfinal | Pablo Cuevas vs Genaro Alberto Olivieri | 3-6 6-1 6-2 |
| Quarterfinal | Juan Pablo Varillas vs Facundo Mena | 6-4 7-5 |
| Quarterfinal | Daniel Dutra da Silva vs Marcelo Tomas Barrios Vera | 6-4 6-3 |
| Quarterfinal | Paul Jubb vs Hernan Casanova | 6-3 7-6(4) |
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