U.S. Men's Clay Court Championships 2022
ATP 250ClayHouston, United States2 April – 10 April 2022Prize money: 665,330 USD39 matchesAltitude: 14 mCourt: Medium-fast
Champion Reilly Opelka · Final: 6-3 7-5
Final rounds
| Final | Reilly Opelka vs John Isner | 6-3 7-6(7) |
| Semifinal | John Isner vs Cristian Garin | 4-6 6-3 6-4 |
| Semifinal | Reilly Opelka vs Nick Kyrgios | 6-3 7-5 |
| Quarterfinal | John Isner vs Frances Tiafoe | 6-4 2-6 6-3 |
| Quarterfinal | Cristian Garin vs Taylor Fritz | 6-2 6-7(5) 6-3 |
| Quarterfinal | Nick Kyrgios vs Michael Mmoh | w/o |
| Quarterfinal | Reilly Opelka vs Gijs Brouwer | 6-3 7-5 |
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