Fifth Third Charleston 125 2021
WTA 250ClayCharleston, United States10 April – 18 April 2021Prize money: 235,238 USD43 matchesAltitude: 8 mCourt: Medium
Champion Astra Sharma · Final: 7-5 6-1
Final rounds
| Final | Astra Sharma vs Ons Jabeur | 2-6 7-5 6-1 |
| Semifinal | Astra Sharma vs Camila Osorio | 7-6(5) 6-1 |
| Semifinal | Ons Jabeur vs Danka Kovinic | 6-3 6-0 |
| Quarterfinal | Astra Sharma vs Linda Fruhvirtova | 6-4 6-3 |
| Quarterfinal | Camila Osorio vs Clara Tauson | 6-4 1-0 ret. |
| Quarterfinal | Ons Jabeur vs Nao Hibino | 6-0 6-1 |
| Quarterfinal | Danka Kovinic vs Shelby Rogers | 7-5 6-1 |
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