Santiago 3 challenger · ATP
Santiago 3 challenger 2021
ChallengerClaySantiago, Chile3 October – 10 October 2021Prize money: 52,080 USD43 matchesAltitude: 549 mCourt: Medium-slow
Champion Juan Pablo Varillas · Final: 6-3 6-1
Final rounds
| Final | Juan Pablo Varillas vs Sebastian Baez | 6-4 7-5 |
| Semifinal | Juan Pablo Varillas vs Francisco Cerundolo | 6-3 6-7(8) 6-3 |
| Semifinal | Sebastian Baez vs Nicolas Jarry | 6-4 6-4 |
| Quarterfinal | Francisco Cerundolo vs Gonzalo Lama | 7-6(6) 6-4 |
| Quarterfinal | Nicolas Jarry vs Hugo Dellien | 7-6(4) 6-4 |
| Quarterfinal | Juan Pablo Varillas vs Gerald Melzer | 6-1 6-3 |
| Quarterfinal | Sebastian Baez vs Facundo Mena | 6-3 6-1 |
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