Santiago 2 challenger · ATP
Santiago 2 challenger 2021
ChallengerClaySantiago, Chile10 October – 17 October 2021Prize money: 52,080 USD43 matchesAltitude: 549 mCourt: Slow
Champion Sebastian Baez · Final: 6-3 6-4
Final rounds
| Final | Sebastian Baez vs Felipe Meligeni Rodrigues Alves | 3-6 7-6(6) 6-1 |
| Semifinal | Sebastian Baez vs Marcelo Tomas Barrios Vera | 3-6 6-3 6-4 |
| Semifinal | Felipe Meligeni Rodrigues Alves vs Matheus Pucinelli De Almeida | 6-2 6-4 |
| Quarterfinal | Marcelo Tomas Barrios Vera vs Juan Pablo Varillas | 6-3 6-4 |
| Quarterfinal | Matheus Pucinelli De Almeida vs Francisco Cerundolo | 7-6(3) 2-6 6-4 |
| Quarterfinal | Felipe Meligeni Rodrigues Alves vs Gerald Melzer | 6-3 5-7 7-5 |
| Quarterfinal | Sebastian Baez vs Juan Manuel Cerundolo | 6-3 6-4 |
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