San Diego Open · ATP
San Diego Open 2021
ATP 250HardSan Diego, United States25 September – 4 October 2021Prize money: 661,800 USD39 matchesAltitude: 12 mCourt: Slow
Champion Casper Ruud · Final: 6-3 6-1
Final rounds
| Final | Casper Ruud vs Cameron Norrie | 6-0 6-2 |
| Semifinal | Casper Ruud vs Grigor Dimitrov | 6-4 4-6 6-4 |
| Semifinal | Cameron Norrie vs Andrey Rublev | 3-6 6-3 6-4 |
| Quarterfinal | Grigor Dimitrov vs Aslan Karatsev | 6-1 1-6 6-2 |
| Quarterfinal | Casper Ruud vs Lorenzo Sonego | 6-1 6-4 |
| Quarterfinal | Andrey Rublev vs Diego Schwartzman | 6-1 7-5 |
| Quarterfinal | Cameron Norrie vs Denis Shapovalov | 6-3 6-1 |
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