Knoxville challenger · ATP
Knoxville challenger 2021
ChallengerHard indoorKnoxville, United States7 November – 14 November 2021Prize money: 52,080 USD43 matchesAltitude: 276 mCourt: Fast
Champion Christopher Eubanks · Final: 6-3 7-6(9)
Final rounds
| Final | Christopher Eubanks vs Daniel Altmaier | 6-3 6-4 |
| Semifinal | Daniel Altmaier vs Michael Mmoh | 3-6 6-3 6-4 |
| Semifinal | Christopher Eubanks vs Bjorn Fratangelo | 7-5 7-5 |
| Quarterfinal | Daniel Altmaier vs Jack Sock | 3-6 7-5 7-6(2) |
| Quarterfinal | Michael Mmoh vs Aidan McHugh | 3-6 6-3 6-1 |
| Quarterfinal | Bjorn Fratangelo vs Emilio Nava | 6-4 6-4 |
| Quarterfinal | Christopher Eubanks vs Christian Harrison | 6-3 7-6(9) |
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